Which of the following statements is FALSE about HIV replication?

Question

BlackTom AI · Accepted Answer

We start by listing each statement and assessing its accuracy about HIV replication.
Option a: 'Viral DNA is produced through reverse transcription.' This is true. HIV uses reverse transcriptase to convert its RNA genome into DNA, which is then integrated into the host genome.
Option b: 'The HIV virus matures by protease releasing individual HIV proteins.' This is true. The viral protease cleaves Gag and Gag-Pol polyproteins to produce mature, functional viral proteins during virion maturation.
Option c: 'The fusion of HIV to host cells is blocked by Reverse Transcriptase.' This is false. Fusion of HIV with the host cell membrane is mediated by the envelope glycoprotein gp120/gp41 and requires CD4 and a coreceptor; reverse transcriptase does not block the fusion step. Inhibitors that block fusion act differently (e.g., fusion inhibitors), but RT inhibitors do not prevent fusion directly.
Option d: 'Viral DNA can integrate into host DNA.' This is true. The integrated viral DNA (provirus) is a key step after reverse transcription and nuclear import, facilitated by integrase.
In summary, the only statement that is incorrect is option c, as it misattributes the fusion-blocking role to Reverse Transcriptase rather than recognizing that fusion is a separate entry process and blocked by other mechanisms.

2025-PSB-MIC1IPE(SP-T3-FT) - INFECTIONS, PANDEMICS AND EPIDEMICS

Which of the following statements is FALSE about HIV replication?

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