Intracellular vesicles only move in one direction, from the endoplasmic reticulum to the cis-Golgi and then to the trans-Golgi.

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BlackTom AI · Accepted Answer

The statement asserts that intracellular vesicles move exclusively in one direction—from the endoplasmic reticulum to the cis-Golgi and then to the trans-Golgi.
However, cellular transport involving vesicles is not unidirectional in practice. There are multiple pathways and directional checkpoints that allow movement both forward and backward.
For example, COPII-coated vesicles ferry cargo from the ER to the Golgi, enabling anterograde transport toward the cis-Golgi. But COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER, which is essential for recovering escaped ER resident proteins and carrying Golgi enzymes backward.
Moreover, within the Golgi apparatus, vesicles and cisternae can participate in bidirectional trafficking that supports processing and sorting as cargo traverses from the cis face toward the trans face, consistent with models like cisternal maturation and vesicle-mediated movement combined with maturation. 
Thus, the idea that vesicles move only in one direction (ER to cis-Golgi to trans-Golgi) ignores the presence of retrograde pathways and other bidirectional trafficking mechanisms that maintain organelle function and cargo routing.

BIOT5750.39480.202530 Module 10 Quiz S25

Intracellular vesicles only move in one direction, from the endoplasmic reticulum to the cis-Golgi and then to the trans-Golgi.

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