What is the function of the Pribnow box?

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The question presents: What is the function of the Pribnow box? and notes the answer as 'Sigma subunit protein recognition and binding site', but there are no answer options provided to evaluate. First, I’ll restate the prompt: What is the function of the Pribnow box? The available data includes an attempted answer but no multiple-choice options to assess.

Context about the Pribnow box: In bacterial transcription, the Pribnow box corresponds to the -10 promoter element (consensus sequence roughly TATAAT) that is recognized by the RNA polymerase holoenzyme's sigma factor. Its primary role is to facilitate the melting of DNA and the initiation of transcription by positioning RNA polymerase at the transcription start site and promoting promoter clearance. This is widely taught as part of prokaryotic transcription initiation.

Now, evaluating the provided option: 'Sigma subunit protein recognition and binding site.' This aligns conceptually with the Pribnow box being a promoter element recognized by the sigma factor, but strictly speaking the Pribnow box is a DNA sequence to which the sigma factor and RNA polymerase bind to initiate transcription, not a sigma subunit itself. Therefore, if this were the only option, it would be describing the interaction rather than naming the element; however, the phrasing could be considered partially correct since the sigma factor does interact with promoter elements like the -10 region to initiate transcription.

Since there are no other answer choices to compare, I can’t perform an option-by-option critique. In general, a more precise correct statement would emphasize that the Pribnow box is the promoter element at approximately -10 relative to the transcription start site in bacteria, recognized by the sigma factor that guides RNA polymerase to the promoter. Any option claiming that it is solely a binding site for a sigma subunit should be evaluated for precision: it is a DNA sequence that is recognized by sigma, enabling binding of the RNA polymerase holoenzyme, but it is not itself a protein or subunit.

If additional options were provided, I would assess each one against the canonical role: promoter DNA sequence, recognition by sigma factor, contribution to transcription initiation, and distinction from other promoter elements like the -35 box. Without the full set of choices, a definitive selection cannot be determined from the given data.

BIOT5750.39480.202530 Module 7 Quiz S25

What is the function of the Pribnow box?

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BIOT5750.39480.202530 Module 7 Quiz S25

What is the function of the Pribnow box?

View Explanation

Log in for full answers

Similar Questions

Question at position 19 In eukaryotes, RNA polymerase binds to a _____________ called the ____________ region.protein: transcriptsequence of DNA;transcriptNone of the above, eukaryotes do not use RNA polymerasesequence of DNA; promoterprotein; promoterClear my selection

The nucleotide sequence on a DNA molecule that is involved in the initiation of transcription is called the

In the process of eukaryotic gene expression, the formation of the Transcription Initiation Complex is a critical regulatory step. Which of the following components is correctly matched with its role in this complex at the promoter?

In eukaryotes, where do general transcription initiation factors bind?

Sigma protein subunits in bacteria are responsible for:

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Question at position 19 In eukaryotes, RNA polymerase binds to a _ called the region.protein: transcriptsequence of DNA;transcriptNone of the above, eukaryotes do not use RNA polymerasesequence of DNA; promoterprotein; promoterClear my selection