Question at position 19 In eukaryotes, RNA polymerase binds to a _____________ called the ____________ region.protein: transcriptsequence of DNA;transcriptNone of the above, eukaryotes do not use RNA polymerasesequence of DNA; promoterprotein; promoterClear my selection

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First, restating the question and options to set the stage for analysis: In eukaryotes, RNA polymerase binds to a _____________ called the ____________ region.
Options presented:
- protein: transcript
- sequence of DNA; transcript
- None of the above, eukaryotes do not use RNA polymerase
- sequence of DNA; promoter
- protein; promoter

Option 1: 'protein: transcript' This choice suggests that RNA polymerase binds to a protein called a transcript. That is incorrect because RNA polymerase recognizes DNA sequences, not a protein named transcript, as the binding site, so this misidentifies both the binding molecule and the site.

Option 2: 'sequence of DNA; transcript' Here, the first blank could be 'sequence of DNA' or something similar, but the second blank 'transcript' incorrectly names the region. In transcription, RNA polymerase binds to a DNA sequence, and the region is typically called a promoter, not 'transcript.' So this mixes correct and incorrect elements and fails to name the proper region.

Option 3: 'None of the above, eukaryotes do not use RNA polymerase' This is factually false; eukaryotes do use RNA polymerases (I, II, III) for transcription. Therefore, this option is incorrect.

Option 4: 'sequence of DNA; promoter' This option correctly identifies that RNA polymerase binds to a DNA sequence and that the binding region is called the promoter. In eukaryotes, transcription initiation involves promoter regions such as the TATA box or other promoter elements to recruit RNA polymerase II and general transcription factors, making this the accurate pairing.

Option 5: 'protein; promoter' The second part correctly mentions promoter, but the binding partner is wrong: RNA polymerase binds to DNA sequences (the promoter) rather than to a protein. This makes the statement partly incorrect and leads to an overall incorrect choice.

Summary of reasoning across options: Several incorrect choices misidentify either the binding partner (protein vs. DNA sequence) or the region name (transcript vs. promoter). The only option that accurately captures both the binding substrate (DNA sequence) and the correct region name (promoter) is option 4, 'sequence of DNA; promoter'. The other options contain conceptual mistakes about what RNA polymerase binds to and which region initiates transcription in eukaryotes.

Question at position 19 In eukaryotes, RNA polymerase binds to a _ called the region.protein: transcriptsequence of DNA;transcriptNone of the above, eukaryotes do not use RNA polymerasesequence of DNA; promoterprotein; promoterClear my selection

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