What is a key feature of the TDR Targets database that makes it particularly useful for drug discovery in neglected diseases?

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BlackTom AI · Accepted Answer

The question centers on identifying a standout feature of the TDR Targets database that aids drug discovery for neglected diseases.
Since the provided answer option is: 'Its search feature can identify essential proteins in bacterial and eukaryotic pathogens with available crystal structures', I will evaluate this claim and its rationale.
First, consider what TDR Targets aims to support: prioritizing potential drug targets in pathogens responsible for neglected diseases. A key advantage in this realm is the ability to pinpoint proteins that are essential for pathogen survival or virulence, because these are the most promising targets for inhibition.
Second, the added emphasis on 'with available crystal structures' highlights a practical aspect for medicinal chemistry: having a crystal structure enables structure-based drug design, such as docking studies, rational modification of lead compounds, and improved understanding of binding interactions. This combination—essentiality data plus structural information—can streamline target selection and accelerate hit-to-lead optimization.
Third, assessing why this option stands out compared to other possible features (even though no other options are provided here): an option focusing only on any essential protein without structural data would be less immediately actionable for drug design; conversely, a feature about in vitro screening alone without target context would be less strategic for target prioritization in neglected diseases. The crystal-structure-enabled facet adds a concrete path to rational design, which is especially valuable when resources are limited and the diseases are under-studied.
Fourth, it’s important to acknowledge limitations: not all essential proteins have known crystal structures, and structure availability can lag behind current knowledge. However, the combination described in the option represents a practical, impactful capability of the database that directly supports downstream medicinal chemistry work.
Given the context of neglected-disease drug discovery, the described feature—identifying essential proteins with available crystal structures—captures a core strength that facilitates targeted, structure-informed drug development.

2254 BIOSC 1544 SEC1000 Quiz #19: Druggability

What is a key feature of the TDR Targets database that makes it particularly useful for drug discovery in neglected diseases?

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