The theory of quantal mechanism of neurotransmission was based on electrophysiology providing evidence for quantal activity in synaptic transmission combined with electron microscopy revealing vesicles near terminal boutons.

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The prompt describes the theory of quantal neurotransmission as being built from two main pieces of evidence: electrophysiology showing quantal events in synaptic transmission and electron microscopy revealing vesicles near terminal boutons.

Option 1: True. This statement aligns with the historical and scientific understanding of quantal neurotransmission. The quantal nature of synaptic transmission was first demonstrated electrophysiologically by observing miniature postsynaptic potentials that occur in discrete, quantized steps, indicating the release of single vesicles of neurotransmitter. Moreover, electron microscopy provided visual confirmation of synaptic vesicles in presynaptic terminals near active zones, supporting the vesicle-based mechanism of release. The combination of these lines of evidence—functional (electrophysiology) and structural (EM)—supported the theory that neurotransmission is quantal, with vesicles acting as the basic units of release.

Option 2: False. This would claim that the quantal mechanism is not supported by electrophysiology or that EM evidence is irrelevant, which contradicts the established body of work. While EM alone could show vesicles, without electrophysiological data demonstrating quantal postsynaptic responses, the conclusion about quantal release would be incomplete. Conversely, electrophysiology without EM would lack the corroborating structural demonstration of vesicles near the release sites. Therefore, saying the theory is not based on both types of evidence misrepresents the historical synthesis that underpins the concept.

Option 3: This option would misinterpret the relationship between the data types, perhaps suggesting that only one type of evidence is necessary. In reality, the robust quantal theory emerged from the convergence of both functional measurements showing discrete release events and ultrastructural observations of vesicles, making reliance on a single type of data insufficient.

Option 4: This choice might imply a broader or different interpretation of what constitutes evidence for quantal transmission, such as excluding EM findings or redefining what constitutes vesicular involvement. However, the canonical account demonstrates that both electrophysiological quantal events and vesicle localization via EM are integral to the theory, so such a statement would be inaccurate.

In summary, the reasoning supports that the true statement is consistent with the dual evidence approach: electrophysiology revealing quantal transmission and EM showing vesicles at presynaptic terminals, which together underpin the quantal theory of neurotransmission. The other options misstate the necessity or interpretation of the evidentiary bases involved.

01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 1

The theory of quantal mechanism of neurotransmission was based on electrophysiology providing evidence for quantal activity in synaptic transmission combined with electron microscopy revealing vesicles near terminal boutons.

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01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 1

The theory of quantal mechanism of neurotransmission was based on electrophysiology providing evidence for quantal activity in synaptic transmission combined with electron microscopy revealing vesicles near terminal boutons.

View Explanation

Log in for full answers

Similar Questions

Which of the following explains why one-way synaptic transmission occurs?

Question at position 3 Select all the ways a neurotransmitter can exit the space between neurons.DiffusionReuptake/recyclingAxon travelEnzymes will digest the neurotransmitter.Immune cells will attack.

At a synapse between two neurons, the dendrites release the neurotransmitters.

Consider a neuron-neuron synapse. Match the description with the presynaptic or postsynaptic neuron. 1: Action potential travels away from the synapse via this neuron. ____ 2: First in the chain of neurons. ____ 3: Second in the chain of neurons. ____ 4: Releases neurotransmitter. ____

Which of the following is the correct sequence of events that occur during synaptic transmission?

What accounts for the longest delay in neuronal signalling?

What accounts for the longest delay in neuronal signalling?

More Practical Tools for Students Powered by AI Study Helper

Making Your Study Simpler

Consider a neuron-neuron synapse. Match the description with the presynaptic or postsynaptic neuron. 1: Action potential travels away from the synapse via this neuron. 2: First in the chain of neurons. 3: Second in the chain of neurons. 4: Releases neurotransmitter.