Questions
NEUR20001_2025_SM2 Assessment for Workshop 9 - neural plasticity and glia
Single choice
Which of the following best characterizes the canonical mechanism of NMDA receptor–dependent long-term depression (LTD) in hippocampal CA1 neurons?
Options
A.Activation of mGluR triggers MAPK signaling, leading to postsynaptic removal of NMDA receptors.
B.AMPA receptor phosphorylation by PKA promotes receptor recycling and stabilizes synaptic weakening.
C.Large calcium influx through NMDA receptors activates CaMKII, strengthening AMPA receptor insertion at the postsynaptic density.
D.Modest, sustained calcium influx through NMDA receptors activates protein phosphatases such as PP1 and calcineurin, leading to AMPA receptor internalization.
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Step-by-Step Analysis
Question restatement: The prompt asks which option best characterizes the canonical mechanism of NMDA receptor–dependent long-term depression (LTD) in hippocampal CA1 neurons.
Option 1: 'Activation of mGluR triggers MAPK signaling, leading to postsynaptic removal of NMDA receptors.' While metabotropic glutamate receptor (mGluR) signaling can contribute to other forms of synaptic plasticity, this description does not match t......Login to view full explanationLog in for full answers
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