A lung stem cell located in the adult mammal that has the potential to give rise to two cell types in the lung, a pneumocyte and goblet cell. Which of the following best describes the potential of this stem cell?

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Examining stem cell potency in the context of adult tissues helps distinguish between potential lineages.
Option 1: totipotent. This would mean the cell could generate all cell types of the organism, including placental and embryonic tissues. An adult lung stem cell does not have such capability, so this is incorrect.
Option 2: multipotent. In the lung, an adult stem cell that can give rise to more than one specialized cell type within the organ—such as pneumocytes and goblet cells—fits the definition of multipotent, which describes a limited but multiple lineage potential within a tissue.
Option 3: pluripotent. Pluripotent cells can form many cell types from multiple germ layers but cannot form extraembryonic tissues. While lung stem cells can form several lung cell types, they do not have the ability to form every tissue type of the body, so this is not the best fit for an adult lung stem cell.
Option 4: unipotent. Unipotent cells can differentiate into only a single cell type, which contradicts the description of giving rise to pneumocytes and goblet cells, i.e., more than one lung-specific cell type.
In summary, the key concept is that adult stem cells in a specific organ can differentiate into a limited set of related cell types within that organ. The ability to produce both a pneumocyte and a goblet cell demonstrates more than one but a restricted lineage potential, which corresponds to multipotent rather than the other potency categories.

A lung stem cell located in the adult mammal that has the potential to give rise to two cell types in the lung, a pneumocyte and goblet cell. Which of the following best describes the potential of this stem cell?

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