This layer of the epidermis is filled with Eleidin, and only found in the palms of the hands and soles of the foot.

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The question asks us to identify the epidermal layer that is filled with Eleidin and is located only on the palms of the hands and the soles of the feet.
Option 1: stratum granulosum. This layer contains keratohyalin granules and is involved in keratinization, but it is not where Eleidin is specifically stored, and it is present in all thick and thin skin, not restricted to palms and soles.
Option 2: stratum basale. This is the deepest epidermal layer where mitosis occurs and where new cells originate; it does not contain Eleidin and is not exclusive to the thick skin of palms and soles.
Option 3: stratum corneum. The outermost protective layer consists of dead, flattened cells filled with keratin; Eleidin is not a feature of this layer, and it spans across all skin surfaces, not limited to palms and soles.
Option 4: stratum lucidum. This is the thin, clear layer between stratum granulosum and stratum corneum, and it is characteristically present only in thick skin areas such as the palms and soles. Eleidin is a vitamin A–derived substance produced during keratinization in this layer, giving it a translucent appearance.
Option 5: stratum spinosum. Also known as the prickly layer, it contains desmosomes that give cells a spiny appearance; it does not house Eleidin and is not restricted to the thick skin of palms and soles.
In summary, the distinctive feature described—Eleidin-filled cells confined to palmar and plantar surfaces—points to the layer that is unique to thick skin and sits just above the granular layer, which matches the description of the stratum lucidum.

BIOLOGY 211-B09C Practice Exam 1

This layer of the epidermis is filled with Eleidin, and only found in the palms of the hands and soles of the foot.

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