The elimination of fluoride occurs MOST likely through which of the following organs?

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BlackTom AI · Accepted Answer

To determine where fluoride is eliminated, we should consider the primary excretory pathways of minerals and compounds in the body.
Option 1: Liver. The liver is a major site for metabolism and detoxification, but fluoride is not primarily excreted via bile from the liver in significant amounts. Misconception: assuming hepatic metabolism is the main route for fluoride disposal.
Option 2: Kidneys. The kidneys filter blood and excrete waste into the urine. Fluoride is largely handled by renal excretion, with fluoride ions appearing in urine as the primary elimination route. This aligns with clinical understanding of fluoride pharmacokinetics and homeostasis.
Option 3: Pancreas. The pancreas functions mainly in digestion (enzymes) and glucose regulation, not in systemic elimination of fluoride. This is a misattribution of excretory role to an organ with a different primary function.
Option 4: Small intestine. The small intestine is involved in nutrient absorption and some enterohepatic circulation, but it is not the main route for fluoride elimination. Any fluoride that reaches the gut may be excreted in feces to a limited extent, but it is not the MOST likely primary organ for elimination.
Option 5: Large intestine. The large intestine handles water absorption and fecal formation; while trace fluoride could be present in stool, the predominant and clinically relevant elimination pathway for fluoride is renal excretion. This option would overstate colonic removal relative to the kidneys.
Overall, when considering the body’s principal route for removing fluoride from circulation, renal (kidney) excretion stands out as the primary mechanism, with urine containing a substantial portion of fluoride eliminated from the body.

OC_DHYG402_202501SPI_1 National Board Practice Exam #1

The elimination of fluoride occurs MOST likely through which of the following organs?

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