What is the renal clearance of amoxycillin in Mr Sam?[Fill in the blank]

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Question restatement: What is the renal clearance of amoxycillin in Mr Sam?

Option analysis:

- Option a: 12.7 mg/min
  This unit shows clearance in mass per time (mg/min), which is not a standard unit for renal clearance, which is typically in volume per time (e.g., mL/min or L/h). Amoxycillin clearance would be expressed as a volume per time, not a mass per time, so this unit mismatch already makes this option implausible. Additionally, even if you attempt to convert, the value 12.7 mg/min does not align with typical clearance values when compared to the other provided options, suggesting it is not correct.

- Option b: 10.6 L/h
  This option uses the correct unit for renal clearance (volume per time). The common pharmacokinetic range for amoxicillin renal clearance in adults is on the order of a few to tens of liters per hour, depending on renal function. Given the provided data, this value is a plausible clearance estimate, and it is the standardized presentation (L/h) for clearance. The presence of L/h rather than mL/min or mg/min aligns with typical pharmacology conventions.

- Option c: 15.6 L/h
  This option is also presented in a correct clearance unit (L/h). While it is not inherently incorrect in isolation, the question provides one specific correct value (as given in the answer field) and the exam design usually has a single intended correct option. If the data or prior calculations indicate 10.6 L/h as the correct clearance for Mr Sam, then 15.6 L/h would be considered overestimating clearance or reflecting a different patient parameter, thus likely incorrect in this context.

- Option d: 0.177 ml/min
  Converting 0.177 mL/min to L/h yields 0.177 mL/min × (1 L / 1000 mL) × (60 min / 1 h) = 0.01062 L/h, which is about 0.0106 L/h, far smaller than the other options. This value is orders of magnitude lower than typical amoxicillin renal clearance in adults and would imply severely reduced renal function or a miscalculation. The mismatch in magnitude compared to the other options makes this incorrect as the standard renal clearance value for amoxicillin in a typical adult patient, assuming normal renal function.

Reasoning summary: Among the options, only those with appropriate units for renal clearance (volume per time) are acceptable; however, there is a specific correct numerical value expected. The 10.6 L/h option uses the correct units and aligns with typical pharmacokinetic reporting, whereas the alternative 12.7 mg/min uses inappropriate units, 15.6 L/h may be plausible but is not the designated correct value in the provided key, and 0.177 ml/min corresponds to an unrealistically low clearance when converted to L/h. Therefore, the most appropriate choice given standard pharmacokinetic conventions and the provided correct answer is 10.6 L/h.

What is the renal clearance of amoxycillin in Mr Sam?[Fill in the blank]

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