Which of the following best describes the main assumption behind QSAR (Quantitative Structure-Activity Relationship) modeling?

Question

BlackTom AI · Accepted Answer

In exploring the core idea behind QSAR modeling, we start from the basic premise that chemical structure encodes information influencing biological activity.
Option 1: 'QSAR assumes that molecules with similar structures often have similar biological activities.' This statement captures the central assumption of QSAR: structural similarity tends to imply similar activity, which underpins the use of descriptors to correlate structure with function.
Option 2 (not provided): Since there is only one available option, there is no alternative to evaluate here. In a broader context, if there were other choices, we would test whether they claim that activity is unpredictable from structure, or that structure-activity relationships are random, both of which would contradict QSAR foundations.
To understand why the stated option aligns with QSAR principles, recall that QSAR models build statistical relationships between molecular descriptors (features derived from structure) and measured activities, relying on the assumption that small structural changes produce predictable changes in activity. When two molecules are structurally similar, their descriptors tend to be similar, and thus their predicted activities are expected to be similar. This is the logic that justifies using structure-based descriptors to forecast biological effects without experimental testing for every compound.
In summary, the core assumption described is the foundational logic of QSAR, tying structural similarity to similarity in biological activity, which enables quantitative inference from structure to function.

2254 BIOSC 1544 SEC1000 Quiz #15: Ligand-based CADD

Which of the following best describes the main assumption behind QSAR (Quantitative Structure-Activity Relationship) modeling?

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