Question at position 22 Assume that a mutation results in an amino acid substitution in the translated polypeptide. What level of protein structure is definitely affected as a result? quaternaryprimary and tertiarytertiaryprimary and secondaryall levels of protein structureprimary

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To analyze what level of protein structure is definitely affected by a mutation that changes an amino acid in the translated polypeptide, we need to recall the levels of protein structure: primary is the linear sequence of amino acids, while secondary, tertiary, and quaternary are higher-order folding and assembly that depend on the primary sequence.

Option 1: quaternary. This level refers to the assembly of multiple polypeptide chains. A single amino acid substitution in one chain does not by itself guarantee an alteration in quaternary structure, especially if the protein functions as a monomer or if the altered residue does not disrupt inter-chain interactions. Therefore, quaternary structure is not definitely affected.

Option 2: primary and tertiary. A missense mutation directly alters the primary structure, since the amino acid order changes. However, while the substitution can influence folding and thus potentially affect tertiary structure, it is not guaranteed that tertiary structure will be affected in all cases. Hence, this option claims an effect on primary and tertiary with certainty, which is not correct.

Option 3: tertiary. While changes in the amino acid sequence can disrupt folding and alter tertiary structure, this is not guaranteed for every substitution. Therefore, tertiary structure is not definitely affected in all scenarios.

Option 4: primary and secondary. Secondary structure (alpha helices, beta sheets) arises from local backbone interactions guided by the primary sequence. A substitution can alter local propensities and potentially affect secondary structure, but this is not guaranteed in every case. Thus, saying both primary and secondary are definitely affected is overstated.

Option 5: all levels of protein structure. If a mutation changes the amino acid, the primary sequence is certainly altered, but higher levels are not guaranteed to change in every instance. Therefore, asserting that all levels are definitely affected is incorrect.

Option 6: primary. A mutation that substitutes one amino acid clearly changes the primary structure, since the linear sequence is altered. This is definitively true, regardless of what happens to higher-order structures in folding or assembly. Therefore, primary is the level that is definitely affected.

In summary, only the primary structure is guaranteed to be altered by a single amino acid substitution, while higher levels may or may not be affected depending on context and the specific residue change.

Question at position 22 Assume that a mutation results in an amino acid substitution in the translated polypeptide. What level of protein structure is definitely affected as a result? quaternaryprimary and tertiarytertiaryprimary and secondaryall levels of protein structureprimary

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Question at position 22 Assume that a mutation results in an amino acid substitution in the translated polypeptide. What level of protein structure is definitely affected as a result? quaternaryprimary and tertiarytertiaryprimary and secondaryall levels of protein structureprimary

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类似问题

Question at position 25 A missense mutation might be affected what level of protein structure?All levels might be affected by a single amino acid substitutionPrimary structure onlyQuaternary structure onlySecondary structure onlyTertiary structure onlyClear my selection

Question at position 22 What level(s) of protein structure could be affected by a nucleotide substitution that results in an amino acid change in a polypeptide?quaternary structureprimary structuretertiary structureThere will be no structural changes.secondary structure

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Question at position 1 What level(s) of protein structure could be affected by a nucleotide substitution that results in an amino acid change in a polypeptide?quaternary structureprimary structureThere will be no structural changes.tertiary structuresecondary structure

A protein composed of more than one polypeptide is known as a:

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The interiors of globular proteins tend to be enriched for aminoacids while the protein surface regions near the aqueous environment tend to be ___________