Structurally, antibodies primarily comprise ______________.

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BlackTom AI · Accepted Answer

In considering the structural composition of antibodies, we evaluate the typical secondary structures that make up the protein domains they possess.

Option 1: Alpha helices. While alpha helices are a common secondary structure in many proteins, antibodies are not primarily composed of them. The immunoglobulin domains that form the core of antibodies are dominated by beta-pleated sheets arranged into a beta-sandwich fold, rather than being rich in alpha helices. Therefore this statement mischaracterizes the dominant structural element of antibodies.

Option 2: Beta sheets. This choice accurately reflects the well-established architecture of immunoglobulin domains. Antibodies consist largely of beta-pleated sheets organized into a beta-sandwich arrangement, with multiple beta strands stabilized by disulfide bonds. This beta-sheet framework underpins the characteristic antibody fold and its stability, making this option correct.

Thus, the reasoning supports beta sheets as the primary structural feature of antibodies, whereas alpha helices do not represent the main structural component.

Structurally, antibodies primarily comprise ______________.

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