What type of interactions does ARG309 form with the ligand?

Question

BlackTom AI · Accepted Answer

The prompt asks about the type of interactions ARG309 forms with the ligand in a given context.

First, note that the answer field specifies the correct choice as: "Both hydrogen bond and salt bridge". However, the provided answer_options array is empty, so we cannot break down and evaluate multiple alternative options against this question because none are listed to compare.

Despite the lack of listed options, we can reason about the interaction types typically observed between an arginine side chain (ARG) and ligands. Arginine has a positively charged guanidinium group at physiological pH, which enables:
- Salt bridge formation: Electrostatic attraction between the positively charged arginine side chain and negatively charged groups on the ligand (such as carboxylate or phosphate groups) is a classic salt bridge interaction. This stabilizes the complex through strong ionic attraction.
- Hydrogen bonding: The guanidinium group can act as a hydrogen bond donor to electronegative atoms (like oxygen or nitrogen atoms on the ligand or within the ligand's functional groups), facilitating directional hydrogen bonds in addition to ionic interactions.

Given these chemical properties, it is plausible that ARG309 can engage in both types of interactions with a ligand, simultaneously or in a complementary manner, depending on the ligand’s functional groups and geometry. Therefore, the statement "Both hydrogen bond and salt bridge" coherently reflects the typical interaction repertoire of arginine with ligands.

If there were other options, we would compare them by checking whether they claim only one interaction type (which would be incomplete for a positively charged, H-bond-capable side chain like arginine) or claim interactions that arginine cannot typically form (e.g., purely covalent bonds in a non-covalent binding context, or interactions that require different side chains). In this case, the claim that ARG309 forms both hydrogen bonds and salt bridges aligns with canonical protein–ligand interaction chemistry.

2254 BIOSC 1544 SEC1000 Homework: BINANA

What type of interactions does ARG309 form with the ligand?

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