Anfinsen experiment demonstrated that protein......... is encoded in a protein's ...............................structure and was dependent on the ................................of Ribonuclease A

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Clarifying the prompt, we’re asked to evaluate which statement about the Anfinsen experiment is correct and why.
Option 1: 'structure/secondary/folding' claims that the protein's structure is encoded in its secondary structure and that folding relates to secondary structure. This is not aligned with Anfinsen’s key insight, which emphasizes the primary sequence (not secondary) as the encoding source for the native fold. Therefore this option misplaces where information about folding is stored.
Option 2: 'folding/secondary/performance' suggests that folding is encoded in secondary structure and that performance (function) follows from that. Since the concept is about primary sequence encoding the folding, and secondary structure is not the primary repository of that information, this choice mixes up the correct level and uses an odd term ('performance') where activity is more standard. This makes it incorrect.
Option 3: 'folding/primary/activity' states that folding is encoded in the primary structure and that the activity depends on proper folding. This matches the essence of Anfinsen’s experiments: the information for the native, functional conformation resides in the amino acid sequence (primary structure), and correct folding is required for enzymatic activity.
Option 4: 'structure/tertiary/activity' asserts that the structure (specifically tertiary) encodes the native state and that activity follows from it. While the native state often corresponds to a specific tertiary arrangement, Anfinsen’s key claim is that this information is contained in the primary sequence, not that tertiary structure encodes folding. This makes the statement inaccurate as a description of the fundamental finding.
In summary, the correct interpretation aligns with the idea that folding is dictated by the primary sequence and that proper folding enables enzymatic activity, while the other options misstate where the encoding resides or what is being linked to activity.

BIOL3611.13541.202610 ClassMeeting7

Anfinsen experiment demonstrated that protein......... is encoded in a protein's ...............................structure and was dependent on the ................................of Ribonuclease A

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