What is a primary advantage of using advanced PDB searches for protein exploration?

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BlackTom AI · Accepted Answer

The question asks: What is a primary advantage of using advanced PDB searches for protein exploration? The provided answer option is: 'Advanced PDB searches allow users to refine queries based on chemical, sequence, and structural attributes.'

Since there are no other answer choices given, we cannot compare this option to alternatives. However, we can explain why this statement accurately reflects a key benefit of advanced PDB searches.

- Refinement by chemical attributes enables filtering for ligands, cofactors, metal ions, or small molecules of interest, which speeds up the identification of relevant structural contexts. 
- Incorporating sequence attributes allows searches to focus on proteins or domains with particular motifs, residues, or evolutionary relationships, facilitating biological relevance and cross-reference with sequence data. 
- Including structural attributes (such as secondary structure, folds, or 3D motif presence) helps scientists pinpoint structures that match desired conformations or functional states, improving the precision of structural hypotheses.

Collectively, the ability to query across chemical, sequence, and structural dimensions makes exploration more targeted, reduces noise from irrelevant entries, and accelerates discovery by returning only those PDB entries that satisfy multiple, specific criteria.

In the absence of additional options, this single statement stands as the asserted primary advantage and aligns with common uses of advanced PDB search functionality.

2254 BIOSC 1544 SEC1000 Quiz #17: Visualizing and Searching for Proteins

What is a primary advantage of using advanced PDB searches for protein exploration?

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