Q3. What are the two components that make up the UniProt Knowledgebase (KB)? Select the two correct options.

Question

BlackTom AI · Accepted Answer

To tackle this question, I’ll evaluate each option against what UniProt KB comprises. 
Option 1: TrEMBL. TrEMBL is indeed one of the two components of the UniProt Knowledgebase, representing automated protein sequence annotations that are not yet curated by Swiss-Prot. This makes it a correct component.
Option 2: Swiss-Prot. Swiss-Prot is the manually reviewed, curated portion of UniProt, providing high-quality annotations. It is the second core component of the UniProt Knowledgebase, so this is also correct.
Option 3: UniPar. UniPar is not listed as a component of the UniProt Knowledgebase; it historically relates to another database concept (or may be confused with UniParc, which is the UniProt Archive). It does not serve as a component of the UniProt KB, so this is incorrect.
Option 4: UniRef. UniRef provides clustered protein sequences to accelerate similarity searches, but it is not one of the two main components of the UniProt Knowledgebase. It is part of a related UniProt infrastructure, not the KB itself, making this option incorrect.
In summary, the two correct components of the UniProt Knowledgebase are TrEMBL and Swiss-Prot, while UniPar (or UniParc) and UniRef do not constitute the two primary KB components.

BCMB20005_2025_SM1 Bioinformatics Quiz

Q3. What are the two components that make up the UniProt Knowledgebase (KB)? Select the two correct options.

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