This question has been regraded.

In class, we discussed the effects of proteosome inhibitors to treat Multiple Myeloma, a form of cancer. The graph on the right shows data from a patient’s myeloma cells that have been exposed to two inhibitors, Carfilzomib and a new drug called D93. Read the axes and legend of the graph carefully. What can you conclude from the data?

Question

This question has been regraded.

In class, we discussed the effects of proteosome inhibitors to treat Multiple Myeloma, a form of cancer.  The graph on the right shows data from a patient’s myeloma cells that have been exposed to two inhibitors, Carfilzomib and a new drug called D93. Read the axes and legend of the graph carefully. What can you conclude from the data?

BlackTom AI · Accepted Answer

The question asks you to interpret the graph showing cell viability for two inhibitors, Carfilzomib and a new drug D93, across a range of concentrations (nM).

Option: 'Carfilzomib has no effect on cell viability.' 
Analysis: In the graph, the bars representing Carfilzomib (as indicated by the legend) are consistently at or near the 100% viability mark across all tested concentrations (6, 9, 13, 20, 30, 44, 67, 100 nM). This pattern indicates that increasing doses of Carfilzomib do not reduce the percentage of viable cells, i.e., Carfilzomib exhibits little to no cytotoxic effect in this experiment. Therefore, this statement is supported by the data.

Understanding the contrast with the other inhibitor: The bars for D93 (the other color in the graph) decrease markedly as the concentration increases, indicating that D93 reduces cell viability at higher doses. Although the options provided do not include explicit statements about D93, the visible data clearly show D93 causing cytotoxicity while Carfilzomib does not, reinforcing that Carfilzomib alone does not decrease viability in this dataset.

If there were other answer choices, a robust evaluation would involve comparing each claim to the trends seen in the graph: (a) a claim of no effect for Carfilzomib matches the near-100% viability across doses, (b) any claim claiming that both drugs are equally effective would be contradicted by the stark difference between the white Carfilzomib bars and the black D93 bars, and (c) a claim that D93 has no effect would be wrong since D93 bars drop viability with concentration.

In summary, the visual data support the statement that Carfilzomib has no significant effect on cell viability under these conditions, making this option consistent with the observed results.

Bio 93 Section CDE 2025 Midterm 1- Section E

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