True or False: Treatment with proteases destroyed the causative agent causing Scrapie.

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True or False:  Treatment with proteases destroyed the causative agent causing Scrapie.

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The question asks us to evaluate the statement: 'Treatment with proteases destroyed the causative agent causing Scrapie.'

Option 1: True. This would assert that applying proteases can eliminate the agent responsible for Scrapie. However, the causative agent of Scrapie is a prion, which is a misfolded protein. Prions are notoriously resistant to proteolytic enzymes; many proteases do not robustly degrade the pathogenic prion protein (PrPSc) and can even be resistant to normal proteolysis. Therefore, this option is incorrect because protease treatment does not reliably destroy the prion.

Option 2: False. This aligns with the established understanding of prion diseases, where the infectious agent is a misfolded protein lacking nucleic acid, and prions show remarkable resistance to proteases and standard sterilization methods. Consequently, proteases do not effectively destroy Scrapie-causing agents, making this statement the accurate one.

In summary, the core idea is that Scrapie is caused by prions, which resist proteolytic breakdown; thus, a claim that proteases destroy the causative agent contradicts the known properties of prions. The false option reflects this resistance, while the true option denies it.

BIOL 271 Case Study 1 Quiz

True or False: Treatment with proteases destroyed the causative agent causing Scrapie.

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