Question at position 67 Which of the following is NOT a human PRION disease?Chronic Traumatic EncephalopathyKuruFatal Familial InsomniaCreutzfeldt-Jakob DiseaseClear my selection

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When evaluating which option is NOT a human prion disease, we need to recall the hallmark features of prion diseases and how each condition presents.
Option 1: Chronic Traumatic Encephalopathy. This condition results from repeated head injuries and is characterized by tau protein pathology (tau tangles) rather than misfolded prion proteins. It is not categorized as a prion disease and is linked to trauma history, not prion transmission. Thus, it stands as the non-prion option among the choices.
Option 2: Kuru. This is a classic human prion disease transmitted through ritual cannibalism in certain populations. It involves misfolded prion proteins and causes rapidly progressive neurodegeneration. Therefore, it is indeed a prion disease, not a non-prion disease.
Option 3: Fatal Familial Insomnia. FFI is caused by a mutation in the PRNP gene, leading to abnormal prion protein formation and a hereditary prion disease. Its inheritance pattern and pathophysiology are quintessential prion disease features, so it is not the correct non-prion choice.
Option 4: Creutzfeldt-Jakob Disease. CJD is the prototypical human prion disease, occurring in sporadic, familial, or iatrogenic forms, with rapid dementia and spongiform changes. This is clearly a prion disease, not the non-prion option.
In summary, understanding the etiologies shows that prion diseases involve misfolded prion proteins and often transmissible or genetic mechanisms, whereas Chronic Traumatic Encephalopathy is driven by repetitive trauma and tauopathy, not prions.

Question at position 67 Which of the following is NOT a human PRION disease?Chronic Traumatic EncephalopathyKuruFatal Familial InsomniaCreutzfeldt-Jakob DiseaseClear my selection

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