Pathological changes in a typical Parkinson disease patient includes: 

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Question: Pathological changes in a typical Parkinson disease patient includes:

Option 1: the death of dopaminergic neurons. This aligns with the core neuropathology of classic Parkinson disease, where loss of dopamine-producing neurons in the substantia nigra pars compacta leads to the hallmark motor symptoms. The downstream consequence is reduced dopaminergic signaling in the striatum, contributing to bradykinesia, rigidity, and tremor.

Option 2: a mutation in the α-synuclein gene. While α-synuclein aggregation forms Lewy bodies and is involved in PD pathology, not all cases are due to a genetic α-synuclein mutation; many are sporadic. Therefore, this describes a possible mechanism in some familial cases but is not the typical or universal pathological change seen in the majority of patients.

Option 3: a meningocele in the spinal cord. A meningocele is a neural tube defect involving protrusion of the meninges; it is unrelated to Parkinson disease pathology and would not be expected as a feature of PD.

Option 4: anencephaly. Anencephaly is a severe congenital brain malformation incompatible with life and bears no relationship to the typical neurodegenerative process of Parkinson disease, making it an incorrect choice in this context.

In evaluating the wording, the most representative and widely recognized pathological change in classic PD is the progressive loss of dopaminergic neurons in the substantia nigra, with Lewy body formation contributing to disease mechanisms. The other options describe processes or conditions not characteristic of the typical PD pathology.

Pathological changes in a typical Parkinson disease patient includes:

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Pathological changes in a typical Parkinson disease patient includes:

View Explanation

Log in for full answers

Similar Questions

How did Mikael Rydberg describe the state of his Parkinson's Disease ~8 years after receiving fetal mesencephalic progenitor transplants. His disease

All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

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Question at position 7 Which of these would you find in an individual with Parkinson's disease?Slow breathing, poor balanceTics, seizuresTremors, rigidity, shuffling gaitHyperreflexia, poor balance, hoarse voice

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In the frozen addicts (movie), the addicts developed _____ from taking ____

Ralph has been demonstrating symptoms of Parkinson's disease (such as hand tremors). The deterioration of neurons using _____________ is most linked to Parkinson's disease in the brain area called _____________.

More Practical Tools for Students Powered by AI Study Helper

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Pathological changes in a typical Parkinson disease patient includes: 

In the frozen addicts (movie), the addicts developed _ from taking

Ralph has been demonstrating symptoms of Parkinson's disease (such as hand tremors). The deterioration of neurons using _ is most linked to Parkinson's disease in the brain area called _.