All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

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BlackTom AI · Accepted Answer

Let's break down each option in the context of Parkinson’s Disease (PD) mechanisms.
Option 1: Microglial activation. Neuroinflammation and microglial activation have been repeatedly implicated in PD, contributing to oxidative stress and neuronal degeneration via cytokine release and a pro-inflammatory environment. This is a well-supported mechanism in PD pathology.
Option 2: Parkin aggregation. Parkin is an E3 ubiquitin ligase involved in tagging damaged mitochondria for degradation (mitophagy). PD is associated with Parkin loss-of-function mutations and deficits in Parkin-mediated mitophagy, but aggregation of Parkin itself is not a commonly recognized pathogenic mechanism in PD. Thus, this option is less supported as a mechanism compared to the others listed.
Option 3: Lysosomal autophagy. Defects in lysosomal autophagy and related pathways (e.g., GBA mutations affecting glucocerebrosidase) are linked to PD, leading to accumulation of misfolded proteins and cellular stress. Impaired autophagy is a widely discussed mechanism in PD.
Option 4: Alpha-synuclein aggregation. The hallmark of PD is alpha-synuclein aggregation into Lewy bodies and Lewy neurites. This is a central, well-established pathogenic mechanism in PD.
Option 5: Mitochondrial dysfunction. Mitochondrial impairments, including complex I dysfunction and impaired mitophagy, are consistently associated with PD and are thought to contribute to dopaminergic neuron vulnerability.
In summary, all listed mechanisms except Parkin aggregation have strong, ongoing support in PD pathology literature. Microglial activation, lysosomal autophagy defects, alpha-synuclein aggregation, and mitochondrial dysfunction each have clear connections to disease mechanisms, whereas Parkin aggregation is not commonly described as a pathogenic mechanism of PD.

01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 3

All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

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01:146:447:01 CLINICAL NEUROBIO CN F25 Exam 3

All the following are mechanisms of action that have been implicated in Parkinson’s Disease EXCEPT:

View Explanation

Log in for full answers

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How did Mikael Rydberg describe the state of his Parkinson's Disease ~8 years after receiving fetal mesencephalic progenitor transplants. His disease

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In the frozen addicts (movie), the addicts developed _____ from taking ____

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