Which of the following rule's from Lipinski's Rule of Five is incorrect?

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BlackTom AI · Accepted Answer

To evaluate the options, I will compare each statement against Lipinski's Rule of Five as it is commonly stated in medicinal chemistry literature.
Option a: 'Number of hydrogen bond donors (OH or NH groups) equal or less than 5.' This matches the Rule of Five, which sets the limit for hydrogen bond donors at ≤ 5. Therefore, this statement is correct.
Option b: 'Molecular weight less than 500 Da.' The rule specifies a molecular weight of ≤ 500 Da. This option aligns with the criterion, so it is correct.
Option c: 'Calculated Log P less than 5.0 (by C log P) or 4.15 (by M log P).' The classic rule uses a maximum logP (octanol-water partition) of ≤ 5.0, regardless of the calculation method. While some calculators provide different numbers (e.g., MlogP around 4.15 in certain contexts), Lipinski’s Rule of Five does not standardly state two different thresholds depending on the method, nor does it specify 4.15 as an accepted threshold. As written, this option introduces an atypical or calculator-specific threshold, which makes it inaccurate as a general statement of Lipinski’s rule. This makes option c incorrect.
Option d: 'Number of hydrogen bond acceptors less than 10.' The rule sets the limit for hydrogen bond acceptors at ≤ 10, so this statement is correct.
Option e: 'Molecular weight more than 500 Da.' Lipinski’s rule specifies MW ≤ 500 Da; stating 'more than 500 Da' as permissible is contrary to the rule. Thus, this statement is incorrect.
In summary, options c and e diverge from the standard Lipinski Rule of Five formulations, while options a, b, and d reflect the established thresholds. The incorrect statements are those that either misstate the logP criterion or misstate the MW criterion, whereas the correct statements accurately reflect the donors, acceptors, and MW limits.

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Which of the following rule's from Lipinski's Rule of Five is incorrect?

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