Question at position 62 SERMS have fewer side effects than using sex hormones to treat osteoporosis.TrueFalse

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BlackTom AI · Accepted Answer

To begin, let's consider the statement in question about SERMs versus sex hormones for osteoporosis treatment.
Option 1: True. The claim is that SERMs have fewer side effects than using sex hormones to treat osteoporosis. In practice, SERMs such as raloxifene act as estrogen receptor modulators, providing estrogen-like effects on bone to help reduce fracture risk, while acting as antagonists in breast tissue and, in some cases, in the uterus. This receptor-selective action can lower the risk of certain estrogen-related adverse effects seen with systemic estrogen therapy, such as breast and endometrial stimulation. However, SERMs are not risk-free; they carry their own potential side effects, notably an increased risk of venous thromboembolism and occasionally hot flashes. Despite these caveats, the overall side effect profile of SERMs is often considered more favorable than that of systemic estrogen therapy for osteoporosis, which historically carries broader risks including thromboembolism, endometrial hyperplasia, and certain cancers depending on duration and context. Thus, the assertion that SERMs have fewer side effects than sex hormones is generally consistent with current pharmacologic reasoning, though clinicians still weigh individual patient risk factors.
Option 2: False. Saying that SERMs have more side effects than sex hormones would contradict the comparative risk considerations described above. While SERMs do have notable risks (e.g., DVT, hot flashes), systemic estrogen therapy for osteoporosis is associated with a distinct and sometimes higher array of risks such as thromboembolic events, endometrial changes, and potential cancers in exposed tissues. The blanket statement that SERMs have more side effects ignores these nuances and the mechanism by which SERMs limit estrogen activity in non-bone tissues. Therefore, labeling the claim as false would require disregarding established pharmacodynamic differences and individual patient risk profiles.
In summary, the comparison hinges on the tissue-selective actions of SERMs versus the broader estrogen effects of sex hormones, with SERMs typically presenting a more favorable side-effect profile in many patient scenarios, though not without notable risks that must be monitored.

Question at position 62 SERMS have fewer side effects than using sex hormones to treat osteoporosis.TrueFalse

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