True or false: Osteoarthritis is considered a systemic disease in the body.
判断题：骨关节炎被认为是一种全身疾病。

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The statement to evaluate is: 'True or false: Osteoarthritis is considered a systemic disease in the body.'

Option 1: True 真正的. This would claim that osteoarthritis is a systemic disease affecting the whole body. In medical understanding, osteoarthritis is primarily a degenerative joint disease that affects cartilage and structures within individual joints. While it can be associated with risk factors (age, obesity, joints overuse) and may have some systemic associations in a broad sense, it is not classified as a systemic (system-wide) inflammatory or autoimmune condition. Therefore, describing OA as systemic would be inaccurate, because the core pathology is localized to joints rather than a pervasive systemic process.

Option 2: False 假. This asserts that osteoarthritis is not a systemic disease and aligns with standard definitions. Osteoarthritis is best characterized as degenerative changes confined largely to affected joints, involving cartilage breakdown, subchondral bone changes, and joint-specific symptoms like pain and stiffness. There can be systemic risk factors that influence the likelihood of OA (e.g., age, genetics, obesity), but these do not make OA a systemic disease in the way conditions like rheumatoid arthritis or systemic lupus erythematosus are systemic. Consequently, labeling osteoarthritis as not systemic is the correct understanding of its nature, since the disease process is localized rather than body-wide.

In summary, option 1 misclassifies OA as systemic by overlooking its primarily joint-specific pathology, whereas option 2 correctly reflects the localized nature of osteoarthritis and its classification as a non-systemic degenerative joint disease.

BIOL 251 杂志251年 Clinical Connections 4: A Joint Effort 临床联系4：共同努力

True or false: Osteoarthritis is considered a systemic disease in the body. 判断题：骨关节炎被认为是一种全身疾病。

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