The nurse administers naloxone [Narcan] to a patient who has received a toxic dose of morphine sulfate. The nurse understands that the naloxone is effective because of which action?

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BlackTom AI · Accepted Answer

The question describes giving naloxone (Narcan) to a patient who has received a toxic dose of morphine sulfate, and asks why naloxone is effective.
The provided answer states: 'Preventing activation of opioid receptors through antagonist actions.' This aligns with the pharmacologic action of naloxone: it is an opioid receptor antagonist that binds to mu (and to some extent kappa and delta) opioid receptors with high affinity, effectively blocking or displacing opioids like morphine from those receptors and preventing receptor activation.
To unpack this further, naloxone works by competing with opioids for opioid receptor binding sites. Because it has a higher affinity for these receptors and acts as an antagonist (not an agonist), it prevents morphine from activating the receptor, thereby reversing opioid-induced effects such as respiratory depression and sedation.
In contrast, if we consider possible alternative mechanisms (which are not listed here but are common distractors in such questions), naloxone does not 'increase endogenous opioid production,' nor does it 'inactivate morphine chemically in the bloodstream.' It also does not 'stimulate receptor activity'—that would be the opposite of an antagonist's function.
The key takeaway is that naloxone reverses opioid toxicity by occupying opioid receptors and blocking further activation, effectively outcompeting morphine for binding and nullifying its downstream effects.
Since the answer options are not provided beyond the one statement, the analysis focuses on the accuracy and implications of this mechanism and why it correctly explains naloxone’s effectiveness in reversing morphine toxicity.

NUIP_2430-001 Reading Quiz 4: Pharmacodynamics (Due 2/3)

The nurse administers naloxone [Narcan] to a patient who has received a toxic dose of morphine sulfate. The nurse understands that the naloxone is effective because of which action?

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