Motor Neuron Disease (MND) is a degenerative disease of the upper and lower motor neurons. People with this disease, eventually die due to:

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Motor Neuron Disease (MND) is a degenerative disease of the upper and lower motor neurons.  People with this disease, eventually die due to:

BlackTom AI · Accepted Answer

The question asks about the cause of death in people with Motor Neuron Disease (MND), which is described as a degenerative disease of the upper and lower motor neurons.
Since the provided answer options are absent, we can still reason about the underlying clinical outcome that is typically fatal in MND.
First, understand that as MND progresses, motor neurons controlling respiratory muscles—such as the diaphragm, intercostal muscles, and bulbar muscles involved in swallowing and protecting the airway—are progressively affected. This leads to weakening and eventual failure of these muscles.
A second key point is that respiratory failure is the primary cause of death in most cases of MND. The decline in respiratory muscle strength reduces the ability to ventilate effectively, leading to hypercapnia (elevated CO2), hypoxemia (low oxygen), and ultimately respiratory failure.
Third, although paralysis of limb muscles and bulbar dysfunction cause significant disability and complications, they are typically not the direct immediate cause of death; it is the compromised respiratory mechanics that precipitate mortality in the disease.
If an option were present, it would likely state something like: 'paralysis/weakness of the respiratory muscles leading to respiratory failure' or 'respiratory failure due to respiratory muscle paralysis.'
In the absence of listed options, the central takeaway is that the terminal event in MND is respiratory failure from progressive weakness of the muscles used in breathing and airway protection, rather than paralysis of non-respiratory muscles alone or non-neuromuscular causes.
Keep in mind that other complications—such as infection from aspiration or poor cough effectiveness—can contribute to morbidity and mortality, but the root mechanism remains respiratory muscle weakness culminating in respiratory failure.

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Motor Neuron Disease (MND) is a degenerative disease of the upper and lower motor neurons. People with this disease, eventually die due to:

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