Which event below would you NOT observe during prophase?

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Question restatement: Which event below would you NOT observe during prophase?

Option 1: 'early mitotic spindle has formed' — In prophase, the spindle apparatus begins to assemble as microtubules organize and centrosomes move apart. So this is something you would observe during prophase, not something you would miss.

Option 2: 'sister chromatids begin to condense' — Chromosome condensation starts in prophase, so observing condensed chromatids during prophase is correct. This is an event you would observe.

Option 3: 'kinetochore microtubules have attached' — Attachment of microtubules to kinetochores typically occurs after the nuclear envelope breaks down, which happens in prometaphase. Therefore, kinetochore attachment is not observed during prophase and is the correct choice for something you would NOT observe in this stage.

Option 4: 'nuclear envelope is intact' — In early prophase the nuclear envelope remains intact, but as prophase progresses toward prometaphase, it begins to break down. Some observations of prophase include an intact envelope, while later prophase features envelope disassembly. Given the question asks what you would NOT observe during prophase, it is still plausible to encounter an intact envelope in early prophase, but many cells are already transitioning as prophase advances. Nevertheless, this option is less definitively excluded from prophase observations than Option 3.

Overall reasoning: The defining transition that marks prophase versus later stages is the onset of kinetochore-microtubule attachment, which is a prometaphase event. Since prophase features spindle formation and chromatin condensation without stable kinetochore attachments, Option 3 stands out as the event you would not observe during prophase, compared to the others which align with prophase activities.

Bio 93 Section CDE 2025 Midterm 2 Practice Exam

Which event below would you NOT observe during prophase?

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