ATP synthase is located in the ________ of the mitochondrion:

Question

BlackTom AI · Accepted Answer

This question asks about the cellular location of ATP synthase within the mitochondrion.

First, recall the basic mitochondrial architecture: the outer mitochondrial membrane surrounds the organelle, while the inner mitochondrial membrane folds inward to form cristae, creating two compartments—the intermembrane space and the matrix.

Next, consider the role of ATP synthase in energy production. The enzyme uses a proton gradient generated across the inner membrane by the electron transport chain. Protons are pumped from the matrix into the intermembrane space, and ATP synthase uses the flow of protons back into the matrix to drive synthesis of ATP from ADP and inorganic phosphate. This functional arrangement requires ATP synthase to be embedded in the inner membrane so it can access both the proton gradient and the matrix where ATP is released.

Given this reasoning, ATP synthase is located in the inner mitochondrial membrane, positioned at the cristae where the proton-morrying gradient is established and utilized.

It is important to distinguish this from other mitochondrial components: the outer membrane lacks the proton gradient machinery, the intermembrane space is a reservoir for protons but does not house the enzyme’s catalytic site, and the matrix is where ATP is released after synthesis. Hence, the inner membrane is the correct structural locale for ATP synthase.

If you were to evaluate alternative options (for example, locations like the outer membrane, intermembrane space, or matrix), you would find that only the inner membrane provides the necessary structural and electrochemical interface for ATP synthase to function properly.

In summary, ATP synthase sits in the inner mitochondrial membrane, precisely where it can couple proton flow to ATP production during oxidative phosphorylation.

2025 T1 DP DPST1051 BLSC1342 Molecules, Cells & Genes

ATP synthase is located in the ________ of the mitochondrion:

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2025 T1 DP DPST1051 BLSC1342 Molecules, Cells & Genes

ATP synthase is located in the ________ of the mitochondrion:

View Explanation

Log in for full answers

Similar Questions

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