After 5 days of starvation, the body is obtaining energy (“running on”) from the breakdown of these stored nutrients:

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In a state of prolonged starvation, the body shifts its energy sources as stores are depleted and metabolic adaptations take place.

Option 1: 0% glucose/glycogen, 10% amino acids/protein and 90% fatty acids/ketones
This reflects the typical progression after several days of fasting: glycogen stores are exhausted, glucose comes mainly from gluconeogenesis using amino acids early on, and fatty acids along with ketone bodies become the primary energy substrates for most tissues, including the brain increasingly relying on ketones. A small but nonzero contribution from amino acids remains possible, but the majority comes from fat-derived sources.

Option 2: 20% glucose/glycogen and 80% fatty acids
After 5 days of starvation, it's unlikely that 20% of energy would still come from glucose/glycogen, since glycogen stores are depleted within about 24 hours in typical humans, and sustained glucose needs are largely met by gluconeogenesis rather than stored glycogen.

Option 3: 60% amino acids/protein, 40% fatty acids/ketones
This overemphasizes protein as the primary energy source. While amino acids do contribute to gluconeogenesis, the body prioritizes fat as the major energy source during prolonged starvation to spare protein. A 60/40 split in favor of amino acids is not consistent with physiological adaptation during extended fasting.

Option 4: 50% glucose/glycogen and 50% fatty acids
As noted, glycogen is depleted within a day or so of starvation; therefore, maintaining a 50/50 split between glucose/glycogen and fatty acids is not physiologically accurate after 5 days of fasting. Glucose from glycogen would be near zero, and ketone production from fat would supply a large portion of energy needs.

Taken together, the first option best aligns with the expected metabolic shift during prolonged starvation, where energy is sourced predominantly from fatty acids and ketone bodies, with minimal to no contribution from stored glucose/glycogen and limited amino acid-derived glucose.

11:709:255:01 NUTRITION AND HEALTH Attendance Quiz 7 from first Metabolism Lecture

After 5 days of starvation, the body is obtaining energy (“running on”) from the breakdown of these stored nutrients:

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