Peripheral proteins are permanently attached to the cell membrane and are typically transmembrane.

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BlackTom AI · Accepted Answer

The statement given is about peripheral proteins and their relationship to the cell membrane.
First, consider what peripheral proteins are: they are associated with the membrane surface, either on the exterior or interior side, and are typically attached through non-covalent interactions with integral proteins or with lipid head groups.
Next, evaluate the claim that they are 'permanently attached' and 'typically transmembrane.' In reality, peripheral proteins are not permanently embedded in the lipid bilayer; they can be removed more easily than integral (membrane-spanning) proteins because their association is non-covalent and surface-facing.
Additionally, being transmembrane is a hallmark of integral (intrinsic) membrane proteins, which span the lipid bilayer. Peripheral proteins, by contrast, do not span the membrane; they are not transmembrane.
Consider also functional nuance: peripheral proteins can link to cytoskeletal elements or participate in signaling and membrane organization without crossing the membrane.
Therefore, the statement is incorrect because peripheral proteins are not permanently attached in a way that makes them transmembrane; they are typically peripherally associated with the membrane surface and can be more readily removed or dissociated than integral, transmembrane proteins.

BIOT5621.36986.202530 Exam I Spring 2025 retry

Peripheral proteins are permanently attached to the cell membrane and are typically transmembrane.

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