Question at position 13 Which of the following lipoproteins normally returns most of the cholesterol to the liver for disposal via reverse transport?ChylomicronsVLDLLDLHDL

Question

BlackTom AI · Accepted Answer

Restating the question and options: The question asks which lipoprotein normally returns most of the cholesterol to the liver for disposal via reverse cholesterol transport. The options are: Chylomicrons, VLDL, LDL, HDL.

Option 1 — Chylomicrons: These lipoproteins are primarily involved in transporting dietary triglycerides from the intestine to tissues after a meal. They carry minimal cholesterol back to the liver, and their main role is not reverse cholesterol transport. This makes this option incorrect for the stated function.

Option 2 — VLDL: Very-low-density lipoprotein carries endogenous triglycerides from the liver to peripheral tissues. While it does contain cholesterol, its principal role is triglyceride transport, and it is not the main vehicle for reverse cholesterol transport. Therefore this choice is not correct.

Option 3 — LDL: Low-density lipoprotein is rich in cholesterol and delivers cholesterol to peripheral tissues. It is often implicated in atherogenesis when in excess, but it is not the particle responsible for returning cholesterol to the liver for disposal. Thus, this option does not describe reverse cholesterol transport.

Option 4 — HDL: High-density lipoprotein is the key player in reverse cholesterol transport. It scavenges cholesterol from peripheral cells and macrophages and delivers it back to the liver for excretion or reuse, which is the classic reverse cholesterol transport pathway. This makes HDL the correct description for the question’s function.

Putting the pieces together: The question emphasizes the return of cholesterol to the liver for disposal, which is characteristic of HDL activity in reverse cholesterol transport, rather than the roles of chylomicrons, VLDL, or LDL in dietary/triglyceride transport or cholesterol delivery to tissues.

Summary of incorrect options: Chylomicrons do not primarily mediate reverse transport; VLDL’s function is endogenous triglyceride delivery; LDL is a cholesterol-delivery particle to tissues and is not the main reverse transporter. Each of these facts conflicts with the stated mechanism, supporting why they are not correct.

Summary of the correct option: HDL’s role in reverse cholesterol transport aligns precisely with the question’s description, making it the appropriate choice based on established lipoprotein physiology.

Question at position 13 Which of the following lipoproteins normally returns most of the cholesterol to the liver for disposal via reverse transport?ChylomicronsVLDLLDLHDL

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