Question16 Complete the following sentence by selecting the most correct answer option from the list below. If all answer options are correct, select 'all answer options are correct'. After consuming a meal rich in free fatty acids, the free fatty acids: Select one alternative: are metabolised to glucose in liver are diverted to the pentose phosphate pathway in skeletal muscle are converted to triglyceride then back to fatty acids before entering muscle are oxidised to CO2 and H2O in the brain all answer options are correct ResetMaximum marks: 1 Flag question undefined

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BlackTom AI · Accepted Answer

The question asks you to complete the sentence about what happens to free fatty acids (FFAs) after consuming a meal rich in FFAs. Here is a step-by-step evaluation of each option:

Option 1: 'are metabolised to glucose in liver' — This is incorrect. FFAs are not converted into glucose in the liver. Gluconeogenesis primarily uses substrates like lactate, alanine, and glycerol; fatty acids are not substrates for glucose production. In fact, fatty acids are a major energy source that are oxidized for ATP, not transformed into glucose.

Option 2: 'are diverted to the pentose phosphate pathway in skeletal muscle' — This is incorrect. The pentose phosphate pathway (PPP) generates NADPH and ribose-5-phosphate for biosynthesis and nucleotide synthesis. It is not the main fate of FFAs in skeletal muscle following a fatty meal. FFAs are stored or oxidized, not shunted into PPP for direct fatty acid metabolism.

Option 3: 'are converted to triglyceride then back to fatty acids before entering muscle' — This is correct. In adipose tissue, FFAs released from a meal are often re-esterified into triglycerides for storage. When needed by tissues such as muscle, these triglycerides are hydrolyzed back into free fatty acids and glycerol to be released and transported to muscle for oxidation. This re-esterification–lipolysis cycle explains the phrasing of this option and aligns with physiology of postprandial FFA handling.

Option 4: 'are oxidised to CO2 and H2O in the brain' — This is incorrect. The brain primarily relies on glucose and, during prolonged fasting, ketone bodies. It does not significantly oxidize fatty acids due to the blood-brain barrier and limited carnitine shuttle access in neurons during normal conditions.

Option 5: 'all answer options are correct' — This is incorrect because options 1, 2, and 4 are not accurate descriptions of postprandial FFA fate, as explained above.

In summary, option 3 reflects the established sequence of fatty acid handling after a fatty meal: FFAs are stored as triglycerides and later mobilized back to fatty acids for use by tissues like muscle, which is why this option is correct while the others do not describe the typical metabolic fate.

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