Which of the following selections correctly lists the sequence of events that occur during intramembranous ossification?

Question

BlackTom AI · Accepted Answer

To address the question, I’ll compare the provided sequence with the known order of events in intramembranous ossification.
Option A: 'Ossification center develops > Calcification > Development of new periosteum > Formation of trabeculae' This starts with the ossification center forming, then mineralization (calcification) occurs, but it places the development of the periosteum before the trabeculae form. In intramembranous ossification, trabeculae are formed as woven bone develops from the mineralized osteoid, and periosteum forms around the forming bone later; placing periosteum development before trabeculae is not consistent with the canonical sequence.
Option B: 'Ossification center develops > Calcification > Formation of trabeculae > Development of new periosteum.' This matches the typical progression: first an ossification center appears, then calcification (mineralization of osteoid), followed by the formation of trabeculae (woven bone trabeculae), and finally the development of periosteum around the bone as the surrounding mesenchyme condenses. This ordering aligns with standard descriptions of intramembranous ossification.
Option C: 'Calcification > Ossification center develops > Formation of trabeculae > Development of new periosteum' This sequence begins with calcification before the ossification center forms. In reality, the ossification center must form first to initiate mineralization, so starting with calcification is incorrect.
Option D: 'Development of new periosteum > Ossification center develops > Calcification > Formation of trabeculae' Here the periosteum forms before the ossification center even appears, which is inconsistent with the process where periosteum forms around a bone after the osteoid and trabeculae have begun to develop. This ordering misplaces periosteal formation relative to the initial bone formation steps.
In summary, the only option that faithfully follows the established sequence for intramembranous ossification is the one that proceeds: ossification center develops → calcification → formation of trabeculae → development of new periosteum. The other choices disrupt this order by misplacing one or more steps relative to the core events of early bone formation and periosteal development.

Which of the following selections correctly lists the sequence of events that occur during intramembranous ossification?

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