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AVBS2001 (ND) Prep for Microscopy Prac 1 in week 2 (1%). Hepatic anatomy and systematic approach

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Time for an abnormal section 001(1) Click the link Links to an external site. to activate your virtual microscopy page. You should see your two normal liver sections, which you can use for comparison. Below them, click on section 001(1) and examine the section. Below are some fragments of text that, together, make up a description for this section. Indicate if you think each are architecture, constituent components, non-constituent components, or interpretation: 1. The section shows a piece of liver. Architecture 2. Central veins, and portal triads can be seen clearly in normal lobular arrangement Architecture 3. The portal triads consist of a bile duct, portal vein and hepatic arteriole though at times these features are indistinct Constituent components 4. The central veins are clearly visible Constituent components 5. The hepatic cords and sinusoids are not clear Constituent components 6. There is widespread vacuolation of the cytoplasm of the hepatocytes. This ranges from many small vacuoles within an eosinophilic cytoplasm in hepatocytes near the central vein; to large vacuoles completely filling and distending the cytoplasm and pushing the small dense nucleus to the side in hepatocytes closer to the portal triads. Constituent components 7. Within the connective tissue of the portal triads there are many individual cells with a small dense round basophilic nucleus and little cytoplasm (lymphocytes). Non-constituent components 8. Widespread periportal hepatic lipidosis Interpretation 9. Reversible cell injury and mild periportal inflammation Interpretation      

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We will evaluate each statement and decide which category best fits for that item, using the given answer keys as a guide while explaining why that category is appropriate or inappropriate. 1. 'The section shows a piece of liver.' — Architecture This describes a description of the overall structure visible in the section, not a specific cellular part or feature. Architecture refers to the general arrangement or framework of the tissue (e.g., liver as an organ, lobular layout, overall tissue plan). Treating this as architecture is appropriate because it sets the context of what is being viewed rather than detailing a particular component. 2. 'Central veins, and portal triads can be seen clearly in normal lobular arrangement' — Architecture Here the statement emphasizes the presence of major organizational features (central veins and portal triads......Login to view full explanation

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