Hemoglobin can bind other ligands including H+, CO2, 2, 3-BPG, and CO. Which of these ligands bind to the same site as O2 ?

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Question restatement: Hemoglobin can bind other ligands including H+, CO2, 2,3-BPG, and CO. Which of these ligands bind to the same site as O2?

Option 1: carbon monoxide. CO binds at the same site as oxygen on the heme iron, forming a strong Fe-CO bond that occupies the O2 binding position. This is the classic reason CO can competitively inhibit O2 binding, so this option correctly identifies the shared site.

Option 2: All of these. This would imply every listed ligand binds at the same site as O2. In reality, the various ligands interact with different sites or mechanisms: CO shares the heme iron site with O2, but CO2, H+, and 2,3-BPG bind at distinct locations or through allosteric effects, not the direct O2-binding pocket.

Option 3: None of these. This claims that none of the listed ligands bind at the O2 site, which contradicts the well-established binding of CO to the heme iron, occupying O2’s location. Therefore this is incorrect.

Option 4: carbon dioxide. CO2 interacts mainly with amino groups, often forming carbamate linkages with N-termini or certain side chains, and it does not occupy the heme iron’s O2-binding site. Thus it does not share the same site as O2.

Option 5: 2,3-BPG. 2,3-BPG binds in the central cavity of deoxygenated hemoglobin, stabilizing the T-state and decreasing O2 affinity, but it does so at a different site than the heme pocket where O2 binds. Therefore it does not share the same site as O2.

Option 6: H+. Protonation effects modulate hemoglobin allosterically and alter oxygen affinity, but this occurs through residues and allosteric transitions rather than occupying the direct O2-binding pocket. Hence it does not bind at the same site as O2.

Summary: Among the listed ligands, only carbon monoxide interacts at the same binding site as oxygen on the heme iron, while the others exert effects via different sites or allosteric mechanisms. This distinguishes CO as the ligand that shares the O2 site, whereas CO2, H+, and 2,3-BPG act through other interactions.

BIOC 440 A Lecture Concept Exercise | 9–10

Hemoglobin can bind other ligands including H+, CO2, 2, 3-BPG, and CO. Which of these ligands bind to the same site as O2 ?

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