Which of the following microbe commonly causes peptic ulcer disease?

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When evaluating which microbe is commonly associated with peptic ulcer disease, we need to consider the most well-established etiologic agents.
Option 1: Helicobacter pylori. This organism is classically linked to peptic ulcers (gastric and duodenal) and gastritis. It colonizes the stomach lining, produces urease to neutralize stomach acid, and triggers inflammatory changes that predispose to ulceration. This association is foundational in medical microbiology and gastroenterology.
Option 2: Escherichia coli. While E. coli can cause a range of GI symptoms, it is not the typical or common cause of peptic ulcers. Most E. coli infections are enteric and do not lead to chronic ulceration of the stomach or duodenum.
Option 3: Neisseria gonorrhoeae. This pathogen is primarily associated with sexually transmitted infections, notably gonorrhea, and does not have a recognized role in peptic ulcer disease.
Option 4: Staphylococcus aureus. S. aureus is a common cause of skin and soft tissue infections and is also implicated in some foodborne illnesses via preformed toxins, but it is not a standard cause of peptic ulcers.
In summary, among the listed microbes, Helicobacter pylori stands out as the organism most consistently and specifically linked to peptic ulcer disease, whereas the others are associated with different clinical syndromes and etiologies.

2025-HS1-NUR20007-Pharmacology and Pathophysiology in Nursing-H1 GI Quiz

Which of the following microbe commonly causes peptic ulcer disease?

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