Transport through the nuclear pore complex is regulated by the molecular switch, Ran. What drives the conformational change in Ran to drive transport across the nuclear membrane?

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BlackTom AI · Accepted Answer

The question asks what drives the conformational change in Ran that facilitates transport across the nuclear membrane.
First, we consider the Ran GTPase cycle: Ran cycles between ON (GTP-bound) and OFF (GDP-bound) states, and these nucleotide-bound states determine Ran’s conformation and interaction partners.
The key event that induces a conformational switch is the hydrolysis of GTP to GDP on Ran. When Ran-GTP is hydrolyzed to Ran-GDP, Ran adopts a different conformation that alters its binding affinities to transport receptors and cargo, driving the directionality of transport through the nuclear pore complex.
A corollary to this is that GTP hydrolysis is spatially regulated: RCC1 in the nucleus maintains Ran in the GTP-bound form, while RanGAP in the cytoplasm stimulates GTP hydrolysis to GDP, thus ensuring cargo release or receptor recycling as transport proceeds.
If one considers alternative statements often seen as distractors, options asserting that merely binding GTP (without hydrolysis) or GDP exchange alone (without hydrolysis) drives the step would be misleading. The conformational change that enables transport is specifically tied to the hydrolysis reaction converting GTP to GDP on Ran, not just nucleotide binding or exchange.
Additionally, since the data shows an empty list for answer options in this prompt, there is no further item to evaluate against, so the analysis centers on the canonical mechanism described above and why hydrolysis is the pivotal event in driving Ran’s conformational change during nuclear transport.

BIOT5750.39480.202530 Module 9 Quiz S25

Transport through the nuclear pore complex is regulated by the molecular switch, Ran. What drives the conformational change in Ran to drive transport across the nuclear membrane?

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