Which of the following is not an intermediate in the glycolytic pathway by which glucose is oxidized to pyruvate

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Framing the question: we are asked to identify which option is not an intermediate in the glycolytic pathway that oxidizes glucose to pyruvate.
Option 1: 3-phosphoglycerate. This molecule appears in glycolysis after the cleavage steps, formed from 1,3-bisphosphoglycerate and preceding phosphoenolpyruvate formation. It is indeed an intermediate.
Option 2: Fructose 1,6-bisphosphate. This is an early glycolytic intermediate produced from fructose-6-phosphate by phosphofructokinase-1, a key regulatory step. It clearly participates in glycolysis.
Option 3: Glucose 1-phosphate. This compound is a glucose derivative used primarily in glycogen metabolism and the salvage pathway; it is not a standard glycolytic intermediate and is not formed along the classical glycolytic sequence from glucose to pyruvate. This makes it the outlier among the listed options.
Option 4: Glyceraldehyde 3-phosphate. This is a central glycolytic intermediate formed from fructose 1,6-bisphosphate via aldolase and is subsequently oxidized to 1,3-bisphosphoglycerate, continuing the pathway toward pyruvate. It is definitely an intermediate.
Option 5: Phosphoenolpyruvate. This high-energy intermediate sits near the end of glycolysis, formed just before pyruvate via the enolase-catalyzed step and then converted to pyruvate by pyruvate kinase. It is a classic glycolytic intermediate.
In summary, every choice except Glucose 1-phosphate aligns with the standard glycolytic sequence from glucose to pyruvate, either as an early, middle, or late intermediate, whereas Glucose 1-phosphate is not part of the glycolytic steps and belongs to other carbohydrate metabolism pathways.

Which of the following is not an intermediate in the glycolytic pathway by which glucose is oxidized to pyruvate

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