Which of the following best describes gliosis?

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BlackTom AI · Accepted Answer

The question asks for the description that best fits gliosis.
Option 1: Proliferation and hypertrophy of glial cells following central nervous system injury. This matches the classic description of gliosis, also known as reactive gliosis or astrocytosis, where glial cells (especially astrocytes) proliferate and enlarge in response to CNS injury to form a glial scar.
Option 2: Formation of new synaptic connections after brain trauma. This describes synaptogenesis or neural remodeling, not gliotic changes in glial cells.
Option 3: Neuronal hyperexcitability in response to injury. This is more characteristic of changes like epileptiform activity or altered neuronal excitability, not the glial response defined as gliosis.
Option 4: Demyelination of axons in the peripheral nervous system. Demyelination describes loss of myelin sheaths, which involves Schwann cells in the PNS, not the CNS glial proliferation and hypertrophy seen in gliosis.
Thus, the statement in option 1 best describes gliosis as the reactive proliferation and enlargement of glial cells after CNS injury.

NEUR20001_2025_SM2 Assessment for Workshop 9 - neural plasticity and glia

Which of the following best describes gliosis?

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