Questions
Questions

APBIO141-031 with labs S10 - CollegeBoard* AP Exam Prep: Multiple Choice

Single choice

The epinephrine signaling pathway plays a role in regulating glucose homeostasis in muscle cells. The signaling pathway is activated by the binding of epinephrine to the beta-2 adrenergic receptor. A simplified model of the epinephrine signaling pathway is represented in Figure 1. The figure presents a simplified model of the epinephrine signaling pathway in muscle cells. A plasma membrane is shown with two transmembrane structures, a Beta-2 Adrenergic Receptor and Adenylyl Cyclase. Epinephrine is shown binding to the extracellular surface of the beta-2 adrenergic receptor. Bound to the cytosolic surface of the receptor is a G protein made up of alpha, beta, and gamma subunits. An arrow indicates that G D P that is bound to the alpha subunit of the G protein is now released from the subunit. A successive arrow points to the G protein subunits dissociated from the adrenergic receptor and the alpha subunit dissociated from a complex of the beta and gamma subunits. G T P is shown binding to the alpha subunit. A successive arrow points from the G T P-modified alpha subunit to the cytosolic region of adenylyl cyclase. Adenylyl cyclase intersects an arrow that points from A T P to Cyclic A M P. A series of arrows follows. An arrow from Cyclic A M P points to Protein Kinase A. An arrow from Protein Kinase A points to Phosphorylase Kinase and is paired with a curved arrow pointing from A T P to A D P. An arrow from Phosphorylase Kinase points to Glycogen Phosphorylase and is paired with a curved arrow pointing from A T P to A D P. An arrow from Glycogen Phosphorylase points to an arrow indicating the conversion of Glycogen to Glucose-1-Phosphate. A final arrow points from Glucose-1-Phosphate to Glycolysis. Figure 1. A simplified model of the epinephrine signaling pathway in muscle cells Which of the following outcomes will most likely result from the irreversible binding of GDP to the G protein?

Options
A.The intracellular concentration of glycogen will increase.
B.The intracellular concentration of glucose-1-phosphate will increase.
C.The intracellular concentration of cyclic AMP will increase.
D.The intracellular concentration of activated protein kinase A will increase.
View Explanation

View Explanation

Verified Answer
Please login to view
Step-by-Step Analysis
To understand the effect of irreversible GDP binding to the G protein in the epinephrine signaling pathway, we must follow the signaling cascade starting at the receptor. Option 1: The intracellular concentration of glycogen will increase. If GDP remains irreversibly bound to the G alpha subunit, the G protein cannot exchange GDP for GTP, so the G protein remains in an inactive state and cannot activate adenylyl cyclase. Without cAMP pro......Login to view full explanation

Log in for full answers

We've collected over 50,000 authentic exam questions and detailed explanations from around the globe. Log in now and get instant access to the answers!

More Practical Tools for Students Powered by AI Study Helper

Join us and instantly unlock extensive past papers & exclusive solutions to get a head start on your studies!