Questions

CHE 008B A01 SS1 2025 Lecture 5 - Friedel-Crafts Reactions

Multiple choice

Which of these reagents will NOT react with benzene by electrophilic aromatic substitution. (select all that apply)

Options

A.HNO3, H2SO4

B.HBr

C.Br2, FeBr3

D.CH3CH2Cl, AlCl3

E.I2

F.SO3, H2SO4

G.H2O, H2SO4

H.1) RCOCl, AlCl3, 2) H3O+

I.CH3CH2Cl

J.all of these react with benzene

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Step-by-Step Analysis

Analyzing which reagents can induce electrophilic aromatic substitution (EAS) on benzene requires distinguishing species that generate a true electrophile under typical EAS conditions from those that do not. Option 1: HNO3, H2SO4 - These acids generate the nitronium ion (NO2+) in a mixed HNO3/H2SO4 system, which is a classic strong electrophile for nitration of benzene. Therefore, this pair WILL react with benzene by EAS. This option is not one of the NOT-react options. Option 2: HBr - Bromination of benzene typically requires a Lewis acid catalyst like FeBr3 and Br2 to generate the brominating electrophile Br+. Simply using HBr does not form a sufficiently strong electrophile to substitute onto benzene under stand......Login to view full explanation

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