With repeated administration of cocaine:

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Question restatement: With repeated administration of cocaine:

Option A: you get tolerance to the locomotor activating effects. In many studies, repeated cocaine exposure actually produces sensitization of locomotor activity rather than tolerance, meaning increased motor activation rather than a diminished response. Therefore this option misstates the typical outcome of repeated exposure.

Option B: None of these are correct. Given that there is a commonly described effect of repeated cocaine exposure on some pharmacodynamic responses, this option would be incorrect if any of the listed consequences (such as tolerance to cardiovascular effects) are supported by evidence. Since the statement about cardiovascular tolerance is presented as the correct answer in the provided data, this option would be inaccurate here.

Option C: you get tolerance to the cardiovascular effects. Repeated cocaine administration can lead to tolerance to certain cardiovascular responses (for example, some of the vasoconstrictive or pressor effects) due to adaptive downregulation or receptor desensitization processes. This aligns with a scenario where chronic exposure reduces the magnitude of some cardiovascular responses, making this option plausible and consistent with what the prompt suggests.

Option D: you get sensitization to local anesthetic effects. Cocaine has local anesthetic properties, but sensitization to these effects is not a commonly described outcome of repeated cocaine exposure. If anything, tolerance or unchanged sensitivity to local anesthetic effects would be more typical, not sensitization, making this option unlikely.

Option E: you get tolerance to the convulsant effects. Cocaine can lower seizure thresholds and provoke convulsions, especially at higher doses. Repeated exposure does not reliably produce tolerance to convulsant effects; in some cases sensitivity or risk can persist or even increase. Thus this option does not fit the usual pattern observed with chronic cocaine exposure.

Summary of reasoning: The locomotor sensitization phenomenon contradicts option A, which claims tolerance for locomotor effects. Option D's suggestion of sensitization to local anesthetic effects is inconsistent with cocaine’s pharmacology. Option E’s claim of tolerance to convulsant effects is not strongly supported by typical chronic-use data. Option B would be correct only if none of the other statements held true, but option C—tolerance to cardiovascular effects—is a recognized outcome in some contexts of repeated cocaine administration, making it the best-supported choice among the options given.

PSYC181_WI25_A00 FINAL EXAM

With repeated administration of cocaine:

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