Which one of the following statements regarding early drug discovery approaches is correct?

Question

BlackTom AI · Accepted Answer

When evaluating early drug discovery approaches, it helps to recall the historical context and how drugs were typically found before modern high-throughput methods.
Option A: 'They often involved compounds found in nature.' This aligns with the historical record, since many early drugs were derived from natural products, such as plant or microbial secondary metabolites, and natural product libraries were a primary source of pharmacologically active compounds.
Option B: 'They relied heavily on genetic information derived from the human genome project.' The Human Genome Project and related genomic data became central much later in drug discovery, guiding target identification and pharmacogenomics, but not as a hallmark of the earliest discovery efforts. This makes the statement inaccurate for the traditional early approaches.
Option C: 'They used protein structural information and molecular docking simulations.' Structure-based drug design with docking is a more modern technique that gained prominence with improvements in computational power and solved protein structures. It is characteristic of later generations of drug discovery rather than the earliest methods, so this claim does not describe the historical approach.
Option D: 'They often involved compounds found in nature.' While this repeats Option A, analyzing its role again, it reinforces the key idea that natural products were a core source of lead compounds in early discovery, contrasting with more synthetic or algorithm-driven strategies that emerged later. The redundancy here also underscores that not all statements in this set capture the traditional approach, but this one does.
Overall, comparing these options, the hallmark of early drug discovery is indeed the reliance on natural products as starting points for therapeutic agents, making the natural compounds statement the historically accurate descriptor among the given choices.

PHRM20001_2025_SM2 REVISION - Quiz 1

Which one of the following statements regarding early drug discovery approaches is correct?

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