What was the goal of Pfizer chemists when they developed the drug UK-92.480?

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BlackTom AI · Accepted Answer

The question asks about the original goal Pfizer chemists had when developing the drug known as UK-92.480. 
Option 1: They were looking for an antihypertensive drug to treat angina pectoris. This is historically accurate: UK-92,480 was pursued as a vasodilator intended to relieve angina by reducing vascular resistance. The target outcome was to alleviate chest pain by improving myocardial blood flow, which aligns with antihypertensive and anti-anginal aims. 
Option 2: They were looking for an erectile dysfunction drug. While UK-92,480 later became famous for its unintended effect on erections, that was discovered during trials after the initial purpose; it was not the original goal, so this option is incorrect as a description of the initial objective. 
Option 3: They were looking for double negative breast cancer drug. There is no historical link between UK-92,480 and breast cancer therapies, making this clearly unrelated and incorrect. 
Option 4: They were looking for a female contraceptive drug. This does not correspond to the development context of UK-92,480 and is not supported by the drug’s early development history. 
Option 5: They were looking for a male contraceptive drug. Similarly, this option misstates the development aim and ignores the actual pharmacological focus on angina; it is not correct. 
In summary, the correct historical objective centered on an antihypertensive/anti-anginal direction, while the later discovered effect on erectile function was incidental rather than the foundational goal.

CHEM151_WI25_A00 Chem151-Midterm

What was the goal of Pfizer chemists when they developed the drug UK-92.480?

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