After smallpox eradication, the next target Is guinea worm disease. After that, the following target is:

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The question presents a sequence of global health targets, asking which disease is the next target after smallpox eradication and guinea worm disease elimination.
Option 1: Leishmaniasis. While leishmaniasis is a significant neglected tropical disease with substantial burden, it has not been positioned as the next global eradication target after guinea worm.
Option 2: Chagas' disease. Chagas is a major parasitic disease, but it has not been designated as the next eradication target following guinea worm in the documented sequence.
Option 3: Yaws. Yaws has historically been highlighted as a candidate for eradication after smallpox, with substantial programmatic attention and a global eradication initiative in past decades; this aligns with the historical sequencing of eradication goals in some public health planning documents.
Option 4: River blindness. River blindness (onchocerciasis) is a major preventable cause of blindness and a focus of control programs, but it has not been identified as the immediate next eradication target after guinea worm in the commonly cited progression.
Option 5: Human African trypanosomiasis and American trypanosomiasis. While both diseases are important to control and eliminate in certain regions, they have not been singled out as the next global eradication target after guinea worm in the standard sequence.
In summary, among the provided choices, Yaws stands out as the candidate historically considered for eradication in the sequence following smallpox and guinea worm, whereas the other diseases are important public health priorities but not framed as the immediate next eradication target in the same context.

After smallpox eradication, the next target Is guinea worm disease. After that, the following target is:

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