Hi! My name is pepsinogen. I live in the stomach and I am inactive. I really want to be active so I can help my body digest proteins. Is there anyone here who can help me become pepsin, an active enzyme?

Question

BlackTom AI · Accepted Answer

Let's break down the scenario and each choice to see how pepsinogen becomes an active enzyme in the stomach.
Option a: NaCl. Sodium chloride is common salt in gastric juice, but it does not activate pepsinogen. It mainly contributes to the acidic environment through overall gastric secretions, not through a direct activation mechanism. Therefore this choice does not explain the activation of pepsinogen.
Option b: HCl. Hydrochloric acid is the key activator here. The highly acidic pH in the stomach catalyzes pepsinogen to pepsin by removing a small peptide fragment, exposing the active site. This processing is well established: pepsinogen + HCl → pepsin. So this option correctly identifies the activator.
Option c: pepsinasterase. This term does not correspond to a known gastric enzyme or activator. There is pepsin and pepsinogen, but no enzyme called pepsinasterase that activates pepsinogen. This is a distractor based on a misnaming or misunderstanding.
Option d: KCl. Potassium chloride is another salt present in some secretions, but it is not the activator for pepsinogen. It does not induce the structural change needed to form active pepsin, so this choice is incorrect.
Option e: pepsinogenasterase. Similar to option c, this invented term does not exist in physiology or biochemistry as an activator. It improperly suggests a separate enzyme with a role in activating pepsinogen, which is not accurate. This is a trick option.
In summary, only HCl (option b) provides the acid environment that converts the inactive pepsinogen into the active enzyme pepsin, while the other options either lack a mechanism for activation or are biologically inaccurate terms.

BIO 181 (001&002) FALL 2025 FA25: Cumulative Exam 4 covers the most important content from Units 1-4: You can do this!!! : ) [Grade is out of 150/900 pts, the same am't of pts for the active learning "easy points" classwork.]

Hi! My name is pepsinogen. I live in the stomach and I am inactive. I really want to be active so I can help my body digest proteins. Is there anyone here who can help me become pepsin, an active enzyme?

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