What are the underlying causes of type 1 and type 2 diabetes? Match each condition with its cause.
1: Type 1 diabetes
2: Type 2 diabetes

Question

BlackTom AI · Accepted Answer

We are given a matching question asking to pair each type of diabetes with its underlying cause, with two items to match: 1) Type 1 diabetes and 2) Type 2 diabetes.

Option set provided for matching includes two potential causes: A) Insulin resistance and B) Autoimmune destruction of the beta cells of the pancreas.

First, consider the cause listed as Insulin resistance. Insulin resistance means the body's cells do not respond effectively to insulin, which is a hallmark feature commonly associated with Type 2 diabetes. This mechanism leads to higher blood glucose as the glucose uptake into cells is impaired despite insulin presence. Therefore, Insulin resistance aligns conceptually with Type 2 diabetes as a primary driver.

Next, examine the cause listed as Autoimmune destruction of the beta cells of the pancreas. This describes an autoimmune process in which the immune system attacks the pancreatic beta cells that produce insulin, resulting in little to no insulin being produced. This mechanism is classically associated with Type 1 diabetes, where insulin production is severely reduced or absent due to beta-cell loss.

Now, apply these associations to the two matching prompts:
- For the Type 1 diabetes item, the autoimmune destruction of the beta cells best fits as its underlying cause, because of the direct link between immune-mediated beta-cell destruction and loss of insulin production.
- For the Type 2 diabetes item, insulin resistance best fits as its underlying cause, because the principal pathology involves tissues becoming less responsive to insulin, often accompanied by compensatory changes in insulin secretion.

It is also worth noting why the alternative pairing within each option is not appropriate, to clarify misconceptions. If one were to pair Insulin resistance with Type 1 diabetes, the reasoning would conflict with the fundamental deficit in insulin production seen in Type 1 rather than a resistance issue. Conversely, pairing Autoimmune destruction with Type 2 diabetes would attribute Type 2 primarily to an autoimmune process, which is not the defining or most characteristic driver of Type 2 in the classic sense, though autoimmune components can sometimes influence disease in complex scenarios.

In summary, the cause labeled Autoimmune destruction of the beta cells of the pancreas corresponds to Type 1 diabetes, while the cause labeled Insulin resistance corresponds to Type 2 diabetes, based on the primary pathophysiologic mechanisms traditionally described for these conditions.

HUMNNTR 2200 SP2025 (15810) Clinical Application: Diabetes

What are the underlying causes of type 1 and type 2 diabetes? Match each condition with its cause. 1: Type 1 diabetes 2: Type 2 diabetes

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