Which complement pathway requires the adaptive arm of the immune response?

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BlackTom AI · Accepted Answer

Start by identifying what the question is asking: which complement pathway requires the adaptive arm of the immune response.
Option 1: Classical pathway. This pathway is initiated by antibodies bound to antigens, which are produced by the adaptive immune system, so its activation relies on adaptive immunity.
Option 2: All 3 pathways. While the classical, lectin, and alternative pathways all converge at the C3 convertase step downstream, only one of them is specifically initiated by an adaptive mechanism (antibody-antigen complexes) rather than innate recognition alone.
Option 3: Alternative pathway. This pathway is part of the innate immune system and is activated directly by pathogen surfaces without the need for antibodies, so it does not require adaptive immunity.
Option 4: Lectin pathway. This pathway is activated by mannose-binding lectin recognizing carbohydrate patterns on pathogens, which is a feature of innate recognition and does not require adaptive immune components.
Putting these details together, the option that explicitly depends on the adaptive arm (antibodies) is the classical pathway, whereas the alternative and lectin pathways are innate-driven, and the statement about \'All 3 pathways\' wrongly implies all require adaptive input. Therefore, the reasoning points toward the classical pathway as the one that requires adaptive immunity.

IMMU2011 2025 Early Feedback Task

Which complement pathway requires the adaptive arm of the immune response?

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